Calendario

Jornada 113/sep.-17/sep./2021
Club Necaxa (Estadio Luis Alves "Zague")1-2Club Tijuana Xolos (Mosaik Stadium)22:30hEstadio Luis Alves "Zague"
Jornada 225/sep.-03/oct./2021
Club Tijuana Xolos (Mosaik Stadium)1-2Puebla FC (Estadio Elquincho)26/sep.-03/oct./202122:30hThe Mosaik Stadium
Jornada 301/oct.-05/oct./2021
Atlas FC (Farol da Saudade)1-0Club Tijuana Xolos (Mosaik Stadium)21:45hFarol da Saudade
Jornada 428/sep.-12/oct./2021
Club Tijuana Xolos (Mosaik Stadium)0-2Juárez FC Bravos (WestfernwehStadion)05/oct.-12/oct./202122:30hThe Mosaik Stadium
Jornada 512/oct.-18/oct./2021
Club León FC (Nou Camp La Catedral)1-1Club Tijuana Xolos (Mosaik Stadium)21:45hNou Camp La Catedral