Calendario

Jornada 113/sep.-17/sep./2021
Club Necaxa (Estadio Luis Alves "Zague")1-2Club Tijuana Xolos (Mosaik Stadium)22:30hEstadio Luis Alves "Zague"
Jornada 225/sep.-03/oct./2021
Club Tijuana Xolos (Mosaik Stadium)1-2Puebla FC (Estadio Elquincho)26/sep.-03/oct./202122:30hThe Mosaik Stadium
Jornada 301/oct.-05/oct./2021
Atlas FC (Farol da Saudade)1-0Club Tijuana Xolos (Mosaik Stadium)21:45hFarol da Saudade
Jornada 428/sep.-12/oct./2021
Club Tijuana Xolos (Mosaik Stadium)0-2Juárez FC Bravos (WestfernwehStadion)05/oct.-12/oct./202122:30hThe Mosaik Stadium
Jornada 512/oct.-18/oct./2021
Club León FC (Nou Camp La Catedral)1-1Club Tijuana Xolos (Mosaik Stadium)21:45hNou Camp La Catedral
Jornada 6
Club América (Elloco Stadium)2-2Club Tijuana Xolos (Mosaik Stadium)
Jornada 7
Club Tijuana Xolos (Mosaik Stadium)3-0Mazatlán FC (Hewani Soccercaps Field)
Jornada 8
Toluca FC (Biondabella Stadio)0-0Club Tijuana Xolos (Mosaik Stadium)
Jornada 9
Club Tijuana Xolos (Mosaik Stadium)1-1Chivas Guadalajara (ANGA Cosmopolitano)
Jornada 10
Pachuca FC (Estadio Santa Costanza)1-1Club Tijuana Xolos (Mosaik Stadium)
Jornada 11
Club Tijuana Xolos (Mosaik Stadium)1-1Pumas UNAM (Estadio El Ocho)
Jornada 12
Atlético Celaya (Wembas Road Arena)2-1Club Tijuana Xolos (Mosaik Stadium)
Jornada 13
Club Tijuana Xolos (Mosaik Stadium)0-0Santos Laguna FC (Saint Genese)
Jornada 14
Club Tijuana Xolos (Mosaik Stadium)2-1Tigres UNAL (Estadio Universitario)
Jornada 15
Cruz Azul (Cachalots Park)2-0Club Tijuana Xolos (Mosaik Stadium)
Jornada 16
Club Tijuana Xolos (Mosaik Stadium)2-2Monterrey FC (El Krone)
Jornada 17
Querétaro FC (Frikilandino Stadio)0-0Club Tijuana Xolos (Mosaik Stadium)