Calendario

Jornada 113/sep.-17/sep./2021
Club Necaxa (Estadio Luis Alves "Zague")1-2Club Tijuana Xolos (Mosaik Stadium)22:30hEstadio Luis Alves "Zague"
Jornada 225/sep.-03/oct./2021
Club América (Elloco Stadium)1-2Club Necaxa (Estadio Luis Alves "Zague")26/sep.-03/oct./202121:45hElloco Stadium
Jornada 301/oct.-05/oct./2021
Club Necaxa (Estadio Luis Alves "Zague")1-2Mazatlán FC (Hewani Soccercaps Field)21:45hEstadio Luis Alves "Zague"
Jornada 428/sep.-12/oct./2021
Toluca FC (Biondabella Stadio)1-1Club Necaxa (Estadio Luis Alves "Zague")05/oct.-12/oct./202122:30hBiondaBella Stadio
Jornada 512/oct.-18/oct./2021
Club Necaxa (Estadio Luis Alves "Zague")0-0Chivas Guadalajara (ANGA Cosmopolitano)22:30hEstadio Luis Alves "Zague"
Jornada 6
Club Necaxa (Estadio Luis Alves "Zague")1-0Pachuca FC (Estadio Santa Costanza)
Jornada 7
Pumas UNAM (Estadio El Ocho)1-1Club Necaxa (Estadio Luis Alves "Zague")
Jornada 8
Club Necaxa (Estadio Luis Alves "Zague")0-1Atlético Celaya (Wembas Road Arena)
Jornada 9
Santos Laguna FC (Saint Genese)1-1Club Necaxa (Estadio Luis Alves "Zague")
Jornada 10
Club Necaxa (Estadio Luis Alves "Zague")0-2Tigres UNAL (Estadio Universitario)
Jornada 11
Cruz Azul (Cachalots Park)0-1Club Necaxa (Estadio Luis Alves "Zague")
Jornada 12
Club Necaxa (Estadio Luis Alves "Zague")1-0Monterrey FC (El Krone)
Jornada 13
Querétaro FC (Frikilandino Stadio)0-1Club Necaxa (Estadio Luis Alves "Zague")
Jornada 14
Club Necaxa (Estadio Luis Alves "Zague")1-1Club León FC (Nou Camp La Catedral)
Jornada 15
Club Necaxa (Estadio Luis Alves "Zague")1-0Puebla FC (Estadio Elquincho)
Jornada 16
Atlas FC (Farol da Saudade)2-0Club Necaxa (Estadio Luis Alves "Zague")
Jornada 17
Club Necaxa (Estadio Luis Alves "Zague")3-0Juárez FC Bravos (WestfernwehStadion)