Calendario

Jornada 113/sep.-17/sep./2021
Club León FC (Nou Camp La Catedral)2-0Atlas FC (Farol da Saudade)23:00hEstadio de La Catedral
Jornada 225/sep.-03/oct./2021
Atlético Celaya (Wembas Road Arena)0-2Club León FC (Nou Camp La Catedral)21:00hWemba's Road Arena
Jornada 301/oct.-05/oct./2021
Club León FC (Nou Camp La Catedral)0-2Juárez FC Bravos (WestfernwehStadion)16:00hNou Camp La Catedral
Jornada 428/sep.-12/oct./2021
Santos Laguna FC (Saint Genese)1-1Club León FC (Nou Camp La Catedral)05/oct.-12/oct./202121:45hStade Saint Genese
Jornada 512/oct.-18/oct./2021
Club León FC (Nou Camp La Catedral)1-1Club Tijuana Xolos (Mosaik Stadium)21:45hNou Camp La Catedral
Jornada 6
Tigres UNAL (Estadio Universitario)0-1Club León FC (Nou Camp La Catedral)
Jornada 7
Club León FC (Nou Camp La Catedral)1-3Club América (Elloco Stadium)
Jornada 8
Cruz Azul (Cachalots Park)2-0Club León FC (Nou Camp La Catedral)
Jornada 9
Club León FC (Nou Camp La Catedral)2-0Mazatlán FC (Hewani Soccercaps Field)
Jornada 10
Monterrey FC (El Krone)0-1Club León FC (Nou Camp La Catedral)
Jornada 11
Club León FC (Nou Camp La Catedral)2-2Toluca FC (Biondabella Stadio)
Jornada 12
Querétaro FC (Frikilandino Stadio)1-3Club León FC (Nou Camp La Catedral)
Jornada 13
Club León FC (Nou Camp La Catedral)0-0Chivas Guadalajara (ANGA Cosmopolitano)
Jornada 14
Club Necaxa (Estadio Luis Alves "Zague")1-1Club León FC (Nou Camp La Catedral)
Jornada 15
Club León FC (Nou Camp La Catedral)2-1Pachuca FC (Estadio Santa Costanza)
Jornada 16
Puebla FC (Estadio Elquincho)1-1Club León FC (Nou Camp La Catedral)
Jornada 17
Club León FC (Nou Camp La Catedral)1-1Pumas UNAM (Estadio El Ocho)