Calendario

Jornada 113/sep.-17/sep./2021
Toluca FC (Biondabella Stadio)1-0Cruz Azul (Cachalots Park)22:45hBiondaBella Stadio
Jornada 225/sep.-03/oct./2021
Cruz Azul (Cachalots Park)0-0Chivas Guadalajara (ANGA Cosmopolitano)26/sep.-03/oct./202116:00hCachalotes Park
Jornada 301/oct.-05/oct./2021
Pachuca FC (Estadio Santa Costanza)1-0Cruz Azul (Cachalots Park)22:30hEstadio Santa Costanza
Jornada 428/sep.-12/oct./2021
Cruz Azul (Cachalots Park)1-1Pumas UNAM (Estadio El Ocho)05/oct.-12/oct./202121:00hCachalotes Park
Jornada 512/oct.-18/oct./2021
Atlético Celaya (Wembas Road Arena)2-0Cruz Azul (Cachalots Park)23:15hWemba's Road Arena
Jornada 6
Cruz Azul (Cachalots Park)1-1Santos Laguna FC (Saint Genese)
Jornada 7
Tigres UNAL (Estadio Universitario)1-0Cruz Azul (Cachalots Park)
Jornada 8
Cruz Azul (Cachalots Park)2-0Club León FC (Nou Camp La Catedral)
Jornada 9
Cruz Azul (Cachalots Park)2-1Monterrey FC (El Krone)
Jornada 10
Querétaro FC (Frikilandino Stadio)0-0Cruz Azul (Cachalots Park)
Jornada 11
Cruz Azul (Cachalots Park)0-1Club Necaxa (Estadio Luis Alves "Zague")
Jornada 12
Puebla FC (Estadio Elquincho)0-1Cruz Azul (Cachalots Park)
Jornada 13
Cruz Azul (Cachalots Park)1-1Atlas FC (Farol da Saudade)
Jornada 14
Juárez FC Bravos (WestfernwehStadion)1-0Cruz Azul (Cachalots Park)
Jornada 15
Cruz Azul (Cachalots Park)2-0Club Tijuana Xolos (Mosaik Stadium)
Jornada 16
Club América (Elloco Stadium)2-2Cruz Azul (Cachalots Park)
Jornada 17
Mazatlán FC (Hewani Soccercaps Field)1-2Cruz Azul (Cachalots Park)